University Community Engagement and Its Effect on University Brand Image

With rising competition between universities in recent years, higher education institutions face increasing pressure to establish a positive brand image among students, faculty, and other university stakeholders for a competitive advantage. While there have been numerous studies showing how corporations’ brand images have been positively affected by corporate social responsibility initiatives, there are few that establish the effect of university community engagement on university brand image. This study uses a mixed-methods approach involving a secondary data analysis, a case study that includes interviews with administrators on the University of Pennsylvania and the Netter Center’s community engagement endeavors and branding, and a survey of 337 US college freshmen and sophomores to examine (i) the current levels of community engagement across universities, (ii) the use of community engagement in current university branding, and (iii) the role that university community engagement plays in affecting students’ brand images of universities. The combination of Carnegie Classification and Campus Compact designation data identifies trends of current university community engagement levels segmented by ranking. The case study provides an example on how a high engagement research university incorporates values of community engagement explicitly and implicitly in current university branding. Survey results show that university community engagement has a statistically significant effect on branding, and that low engagement creates negative effects while high engagement produces positive effects on university brand image; additionally, results show differences in significance of community engagement with segmentation based on demographics and factor level preferences. Based on the research described, this study identifies what Penn, the Netter Center, and other higher education institutions could do to more successfully connect branding and community engagement

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes

Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s. In addition, the inhibitory effects of xanthotoxol on eight CYP450 isoforms and its pharmacokinetic parameters were determined using human liver microsomes. CYP1A2, one of CYP450s, played a key role in the metabolism of xanthotoxol compared to other CYP450s. Xanthotoxol showed stronger inhibition on CYP3A4 and CYP1A2 compared to other isoenzymes with the IC50 of 7.43 μM for CYP3A4 and 27.82 μM for CYP1A2. The values of inhibition kinetic parameters (Ki) were 21.15 μM and 2.22 μM for CYP1A2 and CYP3A4, respectively. The metabolism of xanthotoxol obeyed the typical monophasic Michaelis-Menten kinetics and Vmax, Km, and CLint values were calculated as 0.55 nmol·min−1·mg−1, 8.46 μM, and 0.06 mL·min−1·mg−1. In addition, the results of molecular docking showed that xanthotoxol was bound to CYP1A2 with hydrophobic and π-π bond and CYP3A4 with hydrogen and hydrophobic bond. We predicted the hepatic clearance (CLh) and the CLh value was 15.91 mL·min−1·kg−1 body weight. These data were significant for the application of xanthotoxol and xanthotoxol-containing herbs

Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatogaphy Quadrupole Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS/MS)

Morusin, the important active component of a traditional Chinese medicine, Morus alba L., has been shown to exhibit many vital pharmacological activities. In this study, six recombinant CYP450 supersomes and liver microsomes were used to perform metabolic studies. Chemical inhibition studies and screening assays with recombinant human cytochrome P450s were also used to characterize the CYP450 isoforms involved in morusin metabolism. The morusin metabolites identified varied greatly among different species. Eight metabolites of morusin were detected in the liver microsomes from pigs (PLMs), rats (RLMs), and monkeys (MLMs) by LC-MS/MS and six metabolites were detected in the liver microsomes from humans (HLMs), rabbits (RAMs), and dogs (DLMs). Four metabolites (M1, M2, M5, and M7) were found in all species and hydroxylation was the major metabolic transformation. CYP1A2, CYP2C9, CYP2D6, CYP2E1, CYP3A4, and CYP2C19 contributed differently to the metabolism of morusin. Compared to other CYP450 isoforms, CYP3A4 played the most significant role in the metabolism of morusin in human liver microsomes. These results are significant to better understand the metabolic behaviors of morusin among various species

Proof of User Similarity: the Spatial Measurer of Blockchain

Although proof of work (PoW) consensus dominates the current blockchain-based systems mostly, it has always been criticized for the uneconomic brute-force calculation. As alternatives, energy-conservation and energy-recycling mechanisms heaved in sight. In this paper, we propose proof of user similarity (PoUS), a distinct energy-recycling consensus mechanism, harnessing the valuable computing power to calculate the similarities of users, and enact the calculation results into the packing rule. However, the expensive calculation required in PoUS challenges miners in participating, and may induce plagiarism and lying risks. To resolve these issues, PoUS embraces the best-effort schema by allowing miners to compute partially. Besides, a voting mechanism based on the two-parties computation and Bayesian truth serum is proposed to guarantee privacy-preserved voting and truthful reports. Noticeably, PoUS distinguishes itself in recycling the computing power back to blockchain since it turns the resource wastage to facilitate refined cohort analysis of users, serving as the spatial measurer and enabling a searchable blockchain. We build a prototype of PoUS and compare its performance with PoW. The results show that PoUS outperforms PoW in achieving an average TPS improvement of 24.01% and an average confirmation latency reduction of 43.64%. Besides, PoUS functions well in mirroring the spatial information of users, with negligible computation time and communication cost.Comment: 12 pages,10 figure

DNA builds and strengthens the extracellular matrix in Myxococcus xanthus biofilms by interacting with exopolysaccharides.

One intriguing discovery in modern microbiology is the extensive presence of extracellular DNA (eDNA) within biofilms of various bacterial species. Although several biological functions have been suggested for eDNA, including involvement in biofilm formation, the detailed mechanism of eDNA integration into biofilm architecture is still poorly understood. In the biofilms formed by Myxococcus xanthus, a Gram-negative soil bacterium with complex morphogenesis and social behaviors, DNA was found within both extracted and native extracellular matrices (ECM). Further examination revealed that these eDNA molecules formed well organized structures that were similar in appearance to the organization of exopolysaccharides (EPS) in ECM. Biochemical and image analyses confirmed that eDNA bound to and colocalized with EPS within the ECM of starvation biofilms and fruiting bodies. In addition, ECM containing eDNA exhibited greater physical strength and biological stress resistance compared to DNase I treated ECM. Taken together, these findings demonstrate that DNA interacts with EPS and strengthens biofilm structures in M. xanthus

Experimental 5G New Radio integration with VLC

International audienceIn this paper, integration of 5G New Radio (5G NR) with a Visible Light Communication (VLC) downlink architecture is proposed. This scheme combines two complementary wireless technologies: upcoming 5G NR and VLC to offer indoor enhanced wireless hybrid access able to provide each User Equipment (UE) with very high data rate and positioning support. The data transmission of the 5G NR frame over VLC has been implemented. This represents a novel approach to transmitting 5G NR over VLC by hardware experimentation based on Universal Software Radio Peripheral (USRP). The experiment results show that the proposed scheme with Quadrature Phase Shift Keying (QPSK) mapping achieves a data rate of 14.4 M bits/s and an Error Vector Magnitude (EVM) of 4.78% for a 55 cm free space transmission span